Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9272958 | 0.84 | HDAC1 (0.56) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL7397257 | 0.84 | KMT2A (0.56) | CYP19A1PDE4BPOLBHDAC1HDAC2 | |
| SCHEMBL7359707 | 0.81 | POLB (0.68) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL7353001 | 0.81 | KDM4E (0.66) | PDE4ACYP19A1PDE4BPDE4CPDE4D | |
| SCHEMBL1157387 | 0.81 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7362499 | 0.81 | ALDH1A1 (0.61) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL8571660 | 0.79 | KMT2A (0.61) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL6816260 | 0.77 | KMT2A (0.58) | PDE4APDE4BPDE4CPDE4DRECQL | |
| SCHEMBL987135 | 0.77 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7324772 | 0.76 | PDE4B (0.55) | PDE4APDE4BPDE4CPDE4DRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |