Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 17/20 | 0.44 |
| ▸ | MMP9 | P14780 | 15/20 | 0.44 |
| ▸ | MMP1 | P03956 | 13/20 | 0.44 |
| ▸ | MMP13 | P45452 | 11/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.42 |
| ▸ | MMP14 | P50281 | 4/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995717 | 0.76 | ADAM17 (0.59) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL6501736 | 0.75 | MAPK1 (0.46) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL3940974 | 0.74 | ADAM17 (0.52) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL3948064 | 0.74 | MMP9 (0.59) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL3945000 | 0.72 | MMP9 (0.48) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL3948905 | 0.72 | MMP9 (0.46) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL3947474 | 0.72 | MMP9 (0.52) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL3947793 | 0.70 | MMP13 (0.46) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL3945529 | 0.69 | MMP9 (0.43) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL3942768 | 0.69 | ADAM17 (0.52) | ADAM17MMP9MMP1MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225311-B1 | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors | AMERICAN CYANAMID COMPANY | 2001-05-01 | — | — | US | disclosed |