SCHEMBL7397950

SCHEMBL7397950

O=C(O)CC1C(=O)NCc2ccccc2N1CCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.52
TSHR P16473 3/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
MTNR1A P48039 2/20 0.44
HDAC6 Q9UBN7 2/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
MTNR1B P49286 1/20 0.37
CACNA1G O43497 1/20 0.37
CACNA1H O95180 1/20 0.37
CACNA1I Q9P0X4 1/20 0.37
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
XIAP P98170 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8468700 0.77 ALDH1A1 (0.43) ALDH1A1TSHRSMN1; SMN2KDM4EPOLB
SCHEMBL6007674 0.75 HDAC8 (0.62) ALDH1A1TSHRSMN1; SMN2HDAC6HDAC2
SCHEMBL7057266 0.75 HDAC8 (0.62) ALDH1A1TSHRSMN1; SMN2HDAC6HDAC2
SCHEMBL27922960 0.69 MTNR1A (0.51) MTNR1AMTNR1B
SCHEMBL7338319 0.68 PARP1 (0.44) ALDH1A1TSHRSMN1; SMN2MTNR1AMTNR1B
SCHEMBL6696971 0.68 MTNR1A (0.45) ALDH1A1TSHRSMN1; SMN2MTNR1APOLB
SCHEMBL7555403 0.68 DRD3 (0.46) ALDH1A1TSHRSMN1; SMN2
SCHEMBL27661039 0.67 MTNR1A (0.49) ALDH1A1MTNR1AMTNR1B
SCHEMBL7079518 0.66 TSHR (0.36) ALDH1A1TSHRSMN1; SMN2KDM4EPOLB
Trifluoroacetic Acid SCHEMBL7403792 0.66 ALDH1A1 (0.36) ALDH1A1TSHRSMN1; SMN2MTNR1AHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0767792-A4 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2002-11-20 EP claimed
EP-0767792-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-04-16 EP claimed
WO-1996000730-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-01-11 WO claimed