Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 3/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27579439 | 0.82 | KDM1A (0.45) | SIGMAR1CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL1153942 | 0.79 | TACR3 (0.53) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29609235 | 0.76 | AKR1C1 (0.43) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2599391 | 0.76 | AKR1C1 (0.43) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8793998 | 0.75 | HDAC9 (0.42) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1153379 | 0.74 | TACR3 (0.52) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4420303 | 0.74 | SIGMAR1 (0.49) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1153103 | 0.73 | TACR3 (0.75) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL25401436 | 0.73 | MMP8 (0.47) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| Phenylethyl Alcohol SCHEMBL7644433 | 0.73 | SIGMAR1 (0.44) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177169-A1 | 6- [(ARYL AND HETEROARYL)OXY] METHYL]NAPHTHALENE -2-CARBOXIMIDAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-SYNTHELABO (FR) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000066545-A1 | 6-[[(ARYL AND HETEROARYL)OXY] METHYL]NAPHTHALENE -2-CARBOXIMIDAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-SYNTHELABO (FR) | 2000-11-09 | — | — | WO | disclosed |