Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 3/20 | 0.52 |
| ▸ | TACR1 | P25103 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1153942 | 0.85 | TACR3 (0.53) | TACR3TACR1SIGMAR1HDAC9ALDH1A1 | |
| SCHEMBL6251478 | 0.82 | LMNA (0.47) | TACR3TACR1SIGMAR1CYP1A2CYP2C19 | |
| SCHEMBL1153103 | 0.82 | TACR3 (0.75) | TACR3TACR1SIGMAR1HDAC9ALDH1A1 | |
| SCHEMBL2597839 | 0.75 | HDAC9 (0.45) | TACR3TACR1SIGMAR1HDAC9ALDH1A1 | |
| SCHEMBL29609212 | 0.75 | HDAC9 (0.45) | TACR3TACR1SIGMAR1HDAC9ALDH1A1 | |
| SCHEMBL7398453 | 0.74 | SIGMAR1 (0.44) | TACR3TACR1SIGMAR1HDAC9TP53 | |
| SCHEMBL28940851 | 0.72 | MMP8 (0.49) | TACR3TACR1HDAC9TSHR | |
| SCHEMBL6751391 | 0.71 | HDAC9 (0.44) | TACR3TACR1SIGMAR1HDAC9ALDH1A1 | |
| SCHEMBL16116728 | 0.71 | HDAC9 (0.44) | TACR3TACR1SIGMAR1HDAC9ALDH1A1 | |
| SCHEMBL16075939 | 0.68 | TACR3 (0.44) | TACR3TACR1HDAC9HCAR2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257167-B1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2015-07-22 | — | — | EP | disclosed |
| US-8492387-B2 | 2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease | Merck, Sharp & Dohme, Corp. (US) | 2013-07-23 | — | — | US | disclosed |
| US-20110034483-A1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Via EFS | 2011-02-10 | — | — | US | disclosed |
| EP-2257167-A1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009108550-A1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034483-A1 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BACE2, BACE1, APH1B | TACR3 3547/4885TACR1 3422/4885SIGMAR1 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.