Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 11/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741975 | 0.88 | KCNH2 (0.52) | HRH1KCNH2CHRM1CYP2D6USP2 | |
| SCHEMBL741974 | 0.88 | KCNH2 (0.52) | HRH1KCNH2CHRM1CYP2D6USP2 | |
| SCHEMBL740966 | 0.87 | KCNH2 (0.44) | HRH1KCNH2CHRM1CYP2D6USP2 | |
| SCHEMBL741439 | 0.87 | HRH1 (0.46) | HRH1KCNH2CHRM1CYP2D6USP2 | |
| SCHEMBL762727 | 0.87 | KCNH2 (0.51) | HRH1KCNH2CHRM1CYP2D6USP2 | |
| SCHEMBL740730 | 0.87 | HRH1 (0.44) | HRH1KCNH2CHRM1CYP2D6USP2 | |
| SCHEMBL739392 | 0.87 | KCNH2 (0.45) | HRH1KCNH2CHRM1CYP2D6 | |
| SCHEMBL739667 | 0.87 | KCNH2 (0.43) | HRH1KCNH2CHRM1CYP2D6USP2 | |
| SCHEMBL741047 | 0.86 | HRH1 (0.50) | HRH1KCNH2CHRM1CYP2D6USP2 | |
| SCHEMBL741010 | 0.86 | HRH1 (0.50) | HRH1KCNH2CHRM1CYP2D6USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |