Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.44 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | TYK2 | P29597 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765031 | 0.88 | P2RX3 (0.45) | KCNH2HRH1CYP2D6P2RX3P2RX2 | |
| SCHEMBL739857 | 0.87 | HRH1 (0.57) | KCNH2HRH1CYP2D6CHRM1USP2 | |
| SCHEMBL740730 | 0.84 | HRH1 (0.44) | KCNH2HRH1CYP2D6CHRM1ADORA2A | |
| SCHEMBL739392 | 0.84 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1HCRTR1 | |
| SCHEMBL739667 | 0.84 | KCNH2 (0.43) | KCNH2HRH1CYP2D6CHRM1ADORA2A | |
| SCHEMBL741439 | 0.83 | HRH1 (0.46) | KCNH2HRH1CYP2D6CHRM1PROKR1 | |
| SCHEMBL740454 | 0.82 | ADORA2A (0.51) | KCNH2HRH1CYP2D6CHRM1ADORA2A | |
| SCHEMBL740553 | 0.80 | KCNH2 (0.39) | KCNH2HRH1CYP2D6P2RX3P2RX2 | |
| SCHEMBL740554 | 0.80 | KCNH2 (0.39) | KCNH2HRH1CYP2D6P2RX3P2RX2 | |
| SCHEMBL762833 | 0.79 | POLB (0.43) | KCNH2HRH1CYP2D6P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |