⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432318 | 0.73 | — | — | |
| SCHEMBL5530822 | 0.71 | — | — | |
| SCHEMBL4779247 | 0.71 | — | — | |
| SCHEMBL934500 | 0.69 | — | — | |
| SCHEMBL758165 | 0.69 | ALDH1A1 (0.30) | — | |
| SCHEMBL669845 | 0.68 | — | — | |
| SCHEMBL6896644 | 0.67 | — | — | |
| SCHEMBL669844 | 0.67 | — | — | |
| SCHEMBL11267398 | 0.67 | MEN1 (0.36) | — | |
| SCHEMBL253633 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832082-B1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| EP-0749964-B1 | N-Heterocyclyl biphenyl sulfonamides | ASTRAZENECA AB (SE) | 2001-10-04 | — | — | EP | disclosed |
| US-6258817-B1 | PRODRUGS, HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | ZENECA LTD. (GB) | 2001-07-10 | — | — | US | disclosed |
| US-6060475-A | Substituted pyrazin-2-yl-sulphonamide-(3-pyridyl) compounds and uses thereof | ZENECA LIMITED (GB) | 2000-05-09 | — | — | US | disclosed |
| US-5866568-A | ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY | ZENECA LIMITED (GB) | 1999-02-02 | — | — | US | disclosed |
| EP-0832082-A1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1998-04-01 | — | — | EP | disclosed |
| US-5668137-A | N-heterocyclic sulfonamides having endothelin receptor activity | ZENECA LTD. (GB) | 1997-09-16 | — | — | US | disclosed |
| EP-0749964-A1 | N-Heterocyclyl biphenyl sulfonamides | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | disclosed |
| WO-1996040681-A1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1996-12-19 | — | — | WO | disclosed |
| EP-0344414-B1 | 5-Substitued imidazo[4,5-c]pyridines | SEARLE & CO (US) | 1994-10-12 | — | — | EP | disclosed |
| US-5302601-A | Useful in the treatment of diseases mediated by platelet activating factor | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5227384-A | Platelet activating factor antagonist | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5208242-A | 5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0404797-A4 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL)IMIDAZO 4,5-C)PYRIDINES AS PAF ANTAGONISTS | — | 1992-01-22 | — | — | EP | disclosed |
| US-5019581-A | 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity | G. D. SEARLE & CO. (US) | 1991-05-28 | — | — | US | disclosed |
| EP-0404797-A1 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO 4,5-c]PYRIDINES AS PAF ANTAGONISTS. | SEARLE & CO (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4914108-A | TREATMENT OF INFLAMMATION, RESPIRATORY SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1990-04-03 | — | — | US | disclosed |
| EP-0344414-A1 | 5-Substitued imidazo[4,5-c]pyridines | G.D. Searle & Co. (US) | 1989-12-06 | — | — | EP | disclosed |
| WO-1989008653-A1 | 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1989-09-21 | — | — | WO | disclosed |