Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.48 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | TACR2 | P21452 | 5/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.45 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398380 | 0.89 | CTSS (0.53) | CTSSCTSKTACR2CACNA1BPSMB8 | |
| SCHEMBL7401303 | 0.89 | CTSS (0.50) | CTSSCTSKTACR2CACNA1BPSMB8 | |
| SCHEMBL7408154 | 0.89 | CTSS (0.54) | CTSSCTSKTACR2PSMB8PSMB9 | |
| SCHEMBL7446475 | 0.88 | CTSS (0.51) | CTSSCTSKTACR2CACNA1BPSMB8 | |
| SCHEMBL7402336 | 0.87 | CACNA1B (0.55) | CACNA1BYAP1 | |
| SCHEMBL8193256 | 0.87 | CTSS (0.48) | CTSSCTSKTACR2CACNA1BPSMB8 | |
| SCHEMBL7504668 | 0.87 | CTSS (0.51) | CTSSCTSKTACR2PLGPRSS1 | |
| SCHEMBL8193049 | 0.86 | CTSS (0.48) | CTSSCTSKTACR2CACNA1BYAP1 | |
| SCHEMBL7406386 | 0.85 | CACNA1B (0.51) | CACNA1BYAP1 | |
| SCHEMBL7405818 | 0.85 | CACNA1B (0.49) | CACNA1BPSMB1PSMB8PSMB9PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117841-A | USED TO TREAT STROKE, CEREBRAL ISCHEMIA, PAIN, HEAD TRAUMA OR EPILEPSY | WARNER-LAMBERT COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | disclosed |