Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.43 |
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 4/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399448 | 0.76 | HTR4 (0.44) | HTR4ADRA2CHTR1DHTR2BHTR2C | |
| SCHEMBL3718823 | 0.69 | NOTUM (0.47) | HTR4ADRA2CHTR1DHTR2BADRA1B | |
| Hydrochloric Acid SCHEMBL7410340 | 0.68 | NOTUM (0.46) | HTR4ADRA2CHTR1DHTR2BADRA1B | |
| SCHEMBL8805316 | 0.68 | HTR4 (0.59) | HTR4ADRA2CHTR1DHTR2BHTR2C | |
| SCHEMBL14905735 | 0.67 | HTR4 (0.72) | HTR4ADRA2CHTR1DHTR2BHTR2C | |
| Hydrochloric Acid SCHEMBL7248493 | 0.67 | HTR2C (0.79) | HTR4ADRA2CHTR1DHTR2BHTR2C | |
| SCHEMBL7423609 | 0.66 | HTR4 (0.66) | HTR4ADRA2CHTR1DHTR2BHTR2C | |
| SCHEMBL7405403 | 0.66 | HTR4 (0.53) | HTR4ADRA2CHTR1DHTR2BHTR2C | |
| SCHEMBL7401544 | 0.64 | HTR4 (0.64) | HTR4ADRA2CHTR1DHTR2BHTR2C | |
| SCHEMBL7391969 | 0.64 | HTR4 (0.78) | HTR4ADRA2CHTR1DHTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681583-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017071-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-08-04 | — | — | WO | disclosed |