Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 10/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.49 |
| ▸ | HTR1D | P28221 | 3/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 3/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402695 | 0.80 | ALDH1A1 (0.48) | CYP1A2CYP3A4CYP2D6CYP2C9LMNA | |
| SCHEMBL7394362 | 0.73 | HTR4 (0.52) | HTR4 | |
| SCHEMBL7423609 | 0.71 | HTR4 (0.66) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL14905735 | 0.71 | HTR4 (0.72) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| Hydrochloric Acid SCHEMBL9540261 | 0.71 | HTR3A (0.49) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7401544 | 0.70 | HTR4 (0.64) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL8805316 | 0.69 | HTR4 (0.59) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7391969 | 0.69 | HTR4 (0.78) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| Hydrochloric Acid SCHEMBL7248493 | 0.69 | HTR2C (0.79) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL9341467 | 0.69 | HTR4 (0.71) | HTR4CYP1A2CYP2C9PMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696129-A | TREATING GASTROINTESTINAL DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-09 | — | — | US | claimed |
| EP-0662959-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-07-19 | — | — | EP | claimed |
| WO-1994007859-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-14 | — | — | WO | claimed |
| US-5696129-A | TREATING GASTROINTESTINAL DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-09 | — | — | US | disclosed |
| EP-0662959-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007859-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-14 | — | — | WO | disclosed |