Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.64 |
| ▸ | HTR2C | P28335 | 4/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.59 |
| ▸ | HTR1D | P28221 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | HTR2B | P41595 | 3/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 3/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905735 | 0.78 | HTR4 (0.72) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7391969 | 0.74 | HTR4 (0.78) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL1041174 | 0.74 | HTR4 (1.00) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL2939430 | 0.74 | HTR4 (1.00) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7401546 | 0.73 | HTR4 (0.41) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| Hydrochloric Acid SCHEMBL2938877 | 0.73 | HTR2C (1.00) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL8522273 | 0.73 | HTR4 (0.41) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL8804321 | 0.72 | HTR4 (0.67) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL7399422 | 0.71 | HTR4 (0.65) | HTR4HTR2CADRA2CHTR1DADRA1A | |
| SCHEMBL15324691 | 0.71 | HPGD (0.45) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | claimed |
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5580885-A | FOR TREATMENT OF GASTROINTESTINAL, CARDIOVASCULAR OR NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1996-12-03 | — | — | US | disclosed |
| WO-1993005038-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-18 | — | — | WO | disclosed |