Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394661 | 0.87 | EPHX2 (0.36) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL7396702 | 0.84 | ALDH1A1 (0.38) | HSD11B1ALDH1A1KMT2ALMNA | |
| Amantadine SCHEMBL9298521 | 0.83 | HSD11B1 (0.34) | HSD11B1ALDH1A1MEN1KMT2AMME | |
| Amantadine SCHEMBL7399508 | 0.83 | HSD11B1 (0.34) | HSD11B1ALDH1A1MEN1KMT2AMME | |
| SCHEMBL7389645 | 0.81 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7396582 | 0.81 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7400189 | 0.79 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7398631 | 0.79 | ACE (0.45) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7395527 | 0.78 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9298679 | 0.78 | KMT2A (0.36) | ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | disclosed |