Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.36 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416449 | 0.84 | AKR1C2 (0.46) | LMNATP53TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL7413453 | 0.79 | LMNA (0.41) | LMNATP53TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL7396665 | 0.74 | SMN1; SMN2 (0.34) | LMNATP53TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL10546858 | 0.73 | SERPINH1 (0.38) | LMNATSHRSMN1; SMN2SLC6A3SERPINH1 | |
| SCHEMBL27201936 | 0.71 | GAA (0.45) | LMNATSHRSLC6A3ABL1ALDH1A1 | |
| SCHEMBL30689803 | 0.71 | GAA (0.45) | LMNATSHRSLC6A3ABL1ALDH1A1 | |
| SCHEMBL19612159 | 0.70 | KDM4E (0.43) | TSHRSMN1; SMN2SLC6A3SERPINH1ABL1 | |
| SCHEMBL3224195 | 0.70 | ABL1 (0.45) | LMNATSHRSLC6A3SERPINH1ABL1 | |
| SCHEMBL855750 | 0.69 | LMNA (0.52) | LMNATSHRSMN1; SMN2SLC6A3SERPINH1 | |
| SCHEMBL423691 | 0.69 | AKR1C4 (0.60) | TSHRSLC6A3SERPINH1ABL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H1406-H | Process for preparing dibenzofurans via catalytic heteroannulation | RHONE POULENC RORER PHARMACEUTICALS INC. (US) | 1995-01-03 | — | — | US | disclosed |
| US-5288731-A | Antiemetics, antiserotonine agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-02-22 | — | — | US | disclosed |
| US-5246942-A | Central nervous system, anti-emetic and gastric prokinetic activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0559656-A1 | PROCESS FOR PREPARING MULTICYCLIC OXY-CONTAINING RING COMPONENTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| EP-0494140-A4 | DIBENZOFURANCARBOXAMIDES | — | 1992-09-02 | — | — | EP | disclosed |
| EP-0494140-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-07-15 | — | — | EP | disclosed |
| WO-1992009592-A1 | PROCESS FOR PREPARING MULTICYCLIC OXY-CONTAINING RING COMPONENTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-06-11 | — | — | WO | disclosed |
| WO-1992009284-A1 | 2,6-METHANO-2H-1-BENZOXOCINCARBOXAMIDES AS 5-HT3-ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-06-11 | — | — | WO | disclosed |
| WO-1991004738-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-04-18 | — | — | WO | disclosed |
| WO-1989010364-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-11-02 | — | — | WO | disclosed |
| EP-0339950-A2 | Dibenzofurancarboxamides, their use as pharmaceutical agents, a composition containing the same, and a process for the preparation thereof | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-11-02 | — | — | EP | disclosed |