Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399556 | 0.84 | LMNA (0.38) | ALDH1A1TP53HTTLMNAGAA | |
| SCHEMBL9249778 | 0.80 | AKR1C4 (0.53) | AKR1C2AKR1C1AKR1C3AKR1C4ALDH1A1 | |
| SCHEMBL9510268 | 0.77 | ALDH1A1 (0.41) | AKR1C3ALDH1A1HPGDHSD17B10CA1 | |
| SCHEMBL4357324 | 0.71 | RAB9A (0.43) | AKR1C3ALDH1A1HPGDCA1CA2 | |
| SCHEMBL8629633 | 0.69 | MAPT (0.32) | AKR1C3MAPT | |
| SCHEMBL10369790 | 0.68 | KDM4C (0.44) | ALDH1A1KDM4CKDM4EMEN1MAPT | |
| SCHEMBL6289089 | 0.66 | AKR1C2 (0.64) | AKR1C2AKR1C1AKR1C3AKR1C4ALDH1A1 | |
| SCHEMBL4862551 | 0.65 | AKR1C2 (0.69) | AKR1C2AKR1C1AKR1C3AKR1C4ALDH1A1 | |
| SCHEMBL29375230 | 0.65 | AKR1C2 (1.00) | AKR1C2AKR1C1AKR1C3AKR1C4ALDH1A1 | |
| SCHEMBL184603 | 0.65 | AKR1C2 (1.00) | AKR1C2AKR1C1AKR1C3AKR1C4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288731-A | Antiemetics, antiserotonine agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-02-22 | — | — | US | disclosed |
| WO-1992009284-A1 | 2,6-METHANO-2H-1-BENZOXOCINCARBOXAMIDES AS 5-HT3-ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-06-11 | — | — | WO | disclosed |