Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.60 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 2/20 | 0.46 |
| ▸ | STK39 | Q9UEW8 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855750 | 0.85 | LMNA (0.52) | ALDH1A1TSHRABL1SERPINH1ACLY | |
| SCHEMBL4509845 | 0.85 | CA12 (0.52) | AKR1C4AKR1C3AKR1C2AKR1C1PTGS2 | |
| SCHEMBL12478545 | 0.83 | ABL1 (0.46) | AKR1C4AKR1C3AKR1C2AKR1C1TSHR | |
| SCHEMBL30810238 | 0.83 | BCL2L1 (0.47) | PTGS2ALDH1A1CYP3A4ABL1SERPINH1 | |
| SCHEMBL3308973 | 0.83 | BCL2L1 (0.47) | PTGS2ALDH1A1CYP3A4ABL1SERPINH1 | |
| SCHEMBL3489830 | 0.81 | GAA (0.42) | AKR1C4AKR1C3AKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL3203329 | 0.81 | ABL1 (0.45) | ABL1SERPINH1ACLYGAASLC6A4 | |
| SCHEMBL3224195 | 0.81 | ABL1 (0.45) | AKR1C4AKR1C3AKR1C2AKR1C1TSHR | |
| SCHEMBL6410362 | 0.81 | GAA (0.49) | ALDH1A1CYP3A4TSHRHSD17B10ABL1 | |
| SCHEMBL15662614 | 0.81 | ABL1 (0.45) | ABL1SERPINH1ACLYGAASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014063667-A1 | MESOPOROUS PARTICLES, PREPARATION AND USE THEREOF | AGRA GROUP, A.S. (CZ) | 2014-05-01 | — | — | WO | claimed |
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2023-03-09 | — | — | US | disclosed |
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |
| WO-2014063667-A1 | MESOPOROUS PARTICLES, PREPARATION AND USE THEREOF | AGRA GROUP, A.S. (CZ) | 2014-05-01 | — | — | WO | disclosed |
| US-8476194-B2 | Fungicidal compositions including hydrazone derivatives and copper | DOW AGROSCIENCES, LLC (US) | 2013-07-02 | — | — | US | disclosed |
| US-20120021066-A1 | FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER | DOW AGROSCIENCES LLC (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120010075-A1 | SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER | DOW AGROSCIENCES LLC (US) | 2012-01-12 | — | — | US | disclosed |
| US-8003286-B2 | Photoreceptor for electrophotography | HODOGAYA CHEMICAL CO., LTD. (JP) | 2011-08-23 | — | — | US | disclosed |
| US-20100234363-A1 | HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 DATA-HYDROXYSTEROID DEHYDROGENASE | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2010-09-16 | — | — | US | disclosed |
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4939133-A | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4673686-A | CNS MODIFIERS, ANTI-APOMORPHINE ANTIENETIC ACITIVTY/ | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLE DE L'ILE DE FRANCE (FR) | 1987-06-16 | — | — | US | disclosed |
| EP-0221346-A1 | (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| EP-0018830-B1 | SPIROBENZOFURANONES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Chemical Industries, Ltd. (JP) | 1983-06-08 | — | — | EP | disclosed |
| EP-0003084-B1 | SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Takeda Chemical Industries, Ltd. (JP) | 1982-02-24 | — | — | EP | disclosed |
| US-4284644-A | Spirobenzofuranone compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| EP-0018830-A2 | Spirobenzofuranones, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-11-12 | — | — | EP | disclosed |
| EP-0003084-A1 | Spirobenzofuranone compounds, processes for their preparation and their use as medicines | Takeda Chemical Industries, Ltd. (JP) | 1979-07-25 | — | — | EP | disclosed |
| US-4020081-A | FOR COPPER AND NICKEL | GENERAL MILLS CHEMICALS, INC. (US) | 1977-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010075-A1 | SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER | SOD1, CYP51A1, SOD3 | AKR1C4 636/4885AKR1C3 420/4885AKR1C2 704/4885 |
| US-20120021066-A1 | FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER | SOD1, CYP51A1, CYP4Z1 | AKR1C4 494/4885AKR1C3 420/4885AKR1C2 584/4885 |
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | ZC3HAV1, ZC3HAV1L, IL5 | AKR1C4 2216/4885AKR1C3 2529/4885AKR1C2 2852/4885 |
| US-20100234363-A1 | HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 DATA-HYDROXYSTEROID DEHYDROGENASE | HSD11B1, HSD11B2, HSD3B1 | AKR1C4 62/4885AKR1C3 74/4885AKR1C2 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.