Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29771355 | 1.00 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2HPGDHTTPTGDR2 | |
| SCHEMBL11685370 | 1.00 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2HPGDHTTPTGDR2 | |
| SCHEMBL7927335 | 0.91 | ALDH1A1 (0.88) | ALDH1A1SMN1; SMN2HPGDHTTPTGDR2 | |
| SCHEMBL7926214 | 0.91 | ALDH1A1 (0.88) | ALDH1A1SMN1; SMN2HPGDHTTPTGDR2 | |
| SCHEMBL450781 | 0.89 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2HPGDHTTPTGDR2 | |
| SCHEMBL31371989 | 0.88 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2HPGDHTTPTGDR2 | |
| SCHEMBL6914412 | 0.85 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HPGDHTTPTGDR2 | |
| SCHEMBL7987554 | 0.84 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2HPGDHTTPTGDR2 | |
| SCHEMBL3336500 | 0.83 | LMNA (0.56) | ALDH1A1SMN1; SMN2MAPTKMT2APTK2B | |
| SCHEMBL7751521 | 0.83 | LMNA (0.56) | ALDH1A1SMN1; SMN2MAPTKMT2APTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3207031-B1 | ATAXIA TELENGIECTASIA AND RAD3-RELATED (ATR) PROTEIN KINASE INHIBITORS | Atrin Pharmaceuticals LLC (US) | 2021-04-14 | — | — | EP | disclosed |
| US-10196405-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2019-02-05 | — | — | US | disclosed |
| US-9981989-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981989-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2018-05-29 | — | — | US | disclosed |
| US-20170226130-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-08-10 | — | — | US | disclosed |
| US-20170226130-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-08-10 | — | — | US | disclosed |
| US-9663535-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663535-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-05-30 | — | — | US | disclosed |
| WO-2016061097-A1 | ATAXIA TELENGIECTASIA AND RAD3-RELATED (ATR) PROTEIN KINASE INHIBITORS | Atrin Pharmaceuticals LLC (US) | 2016-04-21 | — | — | WO | disclosed |
| US-20160102104-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2016-04-14 | — | — | US | disclosed |
| US-20160102104-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2016-04-14 | — | — | US | disclosed |
| US-5686610-A | Pyridyl piperazine compound | PHARMACIA & UPJOHN COMPANY (US) | 1997-11-11 | — | — | US | disclosed |
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| EP-0541634-A1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226130-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | CHEK2, ATR, CHEK1 | ALDH1A1 4240/4885SMN1; SMN2 999/4885HPGD 3681/4885 |
| US-20160102104-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | ATR, CHEK1, CHEK2 | ALDH1A1 4356/4885SMN1; SMN2 799/4885HPGD 4129/4885 |
| US-10196405-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | CHEK2, ATR, CHEK1 | ALDH1A1 4211/4885SMN1; SMN2 962/4885HPGD 3675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.