Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392537 | 0.91 | ATM (0.52) | LMNAHPGDATMKMT2ANPC1 | |
| SCHEMBL7399625 | 0.87 | ATM (0.51) | LMNAHPGDATMKMT2ANPC1 | |
| SCHEMBL7396668 | 0.85 | ATM (0.48) | ATMOPRM1OPRD1HRH3HDAC1 | |
| SCHEMBL7396482 | 0.73 | ATM (0.45) | LMNAATMOPRM1OPRD1HDAC1 | |
| SCHEMBL29818122 | 0.72 | LMNA (0.77) | LMNAHPGDMMP13KMT2ANPC1 | |
| SCHEMBL7397699 | 0.70 | ATM (0.43) | ATMKMT2AOPRM1OPRD1KCNH2 | |
| SCHEMBL6141382 | 0.70 | ATM (0.43) | ATMKMT2AOPRM1OPRD1KCNH2 | |
| SCHEMBL7390926 | 0.70 | MEN1 (0.43) | LMNAATMKMT2ANPC1HDAC1 | |
| SCHEMBL7396882 | 0.68 | OPRM1 (0.46) | ATMSIGMAR1KMT2AOPRM1OPRD1 | |
| SCHEMBL7396414 | 0.68 | OPRM1 (0.46) | ATMOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183238-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069816-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-23 | — | — | WO | disclosed |