Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399647 | 1.00 | ADRA2B (0.42) | ADRA2BADRA2AADRA2CALDH1A1HSD17B10 | |
| SCHEMBL12764020 | 0.79 | SMN1; SMN2 (0.48) | ADRA2BADRA2AADRA2CALDH1A1HSD17B10 | |
| SCHEMBL6734487 | 0.79 | ALDH1A1 (0.40) | ADRA2BADRA2AADRA2CALDH1A1HSD17B10 | |
| SCHEMBL12820840 | 0.79 | ALDH1A1 (0.40) | ADRA2BADRA2AADRA2CALDH1A1HSD17B10 | |
| SCHEMBL6734489 | 0.79 | ALDH1A1 (0.40) | ADRA2BADRA2AADRA2CALDH1A1HSD17B10 | |
| SCHEMBL9449496 | 0.78 | ALDH1A1 (0.54) | ALDH1A1HSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL8449454 | 0.78 | ADRA2A (0.42) | ADRA2BADRA2AADRA2CALDH1A1HSD17B10 | |
| SCHEMBL13469231 | 0.78 | ADRA2A (0.42) | ADRA2BADRA2AADRA2CALDH1A1HSD17B10 | |
| SCHEMBL9449500 | 0.78 | ALDH1A1 (0.54) | ALDH1A1HSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7369994 | 0.76 | CYP4F2 (0.44) | ALDH1A1HSD17B10CYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330990-A | Antagonists of 5-HT and 5-HT3 receptors, psychological disorders, antinausea | NOVO NORDISK A/S (DK) | 1994-07-19 | — | — | US | disclosed |
| EP-0419397-B1 | Substituted urea compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-06-08 | — | — | EP | disclosed |
| EP-0491770-A1 | SUBSTITUTED UREA COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-01 | — | — | EP | disclosed |
| EP-0419397-A1 | Substituted urea compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1991-03-27 | — | — | EP | disclosed |
| WO-1991003475-A1 | SUBSTITUTED UREA COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-03-21 | — | — | WO | disclosed |