Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphine SCHEMBL9506700 | 0.77 | CYP2D6 (0.41) | CYP2D6TAAR1AOC3RIPK1ADRA2A | |
| SCHEMBL10360017 | 0.77 | RIPK1 (0.45) | CYP2D6TAAR1AOC3RIPK1ADRA2A | |
| Bromide SCHEMBL7400155 | 0.75 | CYP2D6 (0.36) | CYP2D6TAAR1AOC3RIPK1ADRA2A | |
| SCHEMBL8097006 | 0.73 | TAAR1 (0.40) | CYP2D6TAAR1AOC3RIPK1ADRA2A | |
| SCHEMBL14367700 | 0.73 | TAAR1 (0.40) | CYP2D6TAAR1AOC3RIPK1ADRA2A | |
| SCHEMBL8097109 | 0.73 | TAAR1 (0.40) | CYP2D6TAAR1AOC3RIPK1ADRA2A | |
| SCHEMBL17084089 | 0.71 | SLC6A4 (0.42) | TAAR1AOC3RIPK1ADRA2AADRA2C | |
| SCHEMBL17084162 | 0.71 | SLC6A4 (0.42) | TAAR1AOC3RIPK1ADRA2AADRA2C | |
| SCHEMBL16133820 | 0.71 | RIPK1 (0.41) | CYP2D6TAAR1AOC3RIPK1ADRA2A | |
| SCHEMBL16133821 | 0.71 | RIPK1 (0.41) | CYP2D6TAAR1AOC3RIPK1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0587767-A1 | HYDROXYAZIDO DERIVATIVES AND RELATED COMPOUNDS AS RENIN INHIBITORS | SRI INTERNATIONAL (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5268361-A | Containing amide groups | SRI INTERNATIONAL (US) | 1993-12-07 | — | — | US | disclosed |
| WO-1992021696-A1 | HYDROXYAZIDO DERIVATIVES AND RELATED COMPOUNDS AS RENIN INHIBITORS | SRI INTERNATIONAL (US) | 1992-12-10 | — | — | WO | disclosed |