Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 7/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10570343 | 0.87 | MMP13 (0.56) | MMP13MMP8MMP1HTTNPSR1 | |
| SCHEMBL7207708 | 0.83 | MMP13 (0.71) | MMP13MMP8MMP1HTTNPSR1 | |
| SCHEMBL14379753 | 0.80 | MMP13 (0.70) | MMP13MMP8MMP1HTTNPSR1 | |
| SCHEMBL13043580 | 0.79 | ALDH1A1 (0.44) | MMP13MMP8MMP1KMT2A | |
| SCHEMBL24175871 | 0.79 | MMP13 (0.68) | MMP13MMP8MMP1HTTNPSR1 | |
| SCHEMBL7213584 | 0.79 | MMP13 (0.68) | MMP13MMP8MMP1HTTNPSR1 | |
| SCHEMBL24175875 | 0.79 | MMP13 (0.68) | MMP13MMP8MMP1HTTNPSR1 | |
| SCHEMBL20054093 | 0.78 | MMP13 (0.72) | MMP13MMP8MMP1HTTNPSR1 | |
| SCHEMBL7212062 | 0.77 | MMP13 (0.71) | MMP13MMP8MMP1HTTNPSR1 | |
| SCHEMBL8204581 | 0.77 | MMP13 (0.71) | MMP13MMP8MMP1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939628-A4 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0939628-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003164-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |