SCHEMBL7400375

SCHEMBL7400375

CC(C)(C)OC(=O)NCc1c(S(=O)(=O)c2ccccc2)[nH]c2ccc(-c3cccc4ccccc34)cc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.39
MTNR1A P48039 1/20 0.39
MTNR1B P49286 1/20 0.39
HPN P05981 1/20 0.39
KDM4A O75164 1/20 0.38
NQO2 P16083 1/20 0.38
PPARG P37231 3/20 0.37
PPARA Q07869 3/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
PPARD Q03181 1/20 0.37
BRD4 O60885 1/20 0.37
CREBBP Q92793 1/20 0.37
HDAC1 Q13547 1/20 0.36
BRD9 Q9H8M2 1/20 0.36
BAZ2B Q9UIF8 1/20 0.36
BAZ2A Q9UIF9 1/20 0.36
EZH2 Q15910 1/20 0.36
BCHE P06276 1/20 0.36
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7399637 0.83 CXCR2 (0.41) KDM4APPARGCYP2C9CYP2C19BCHE
SCHEMBL7400274 0.80 MTNR1A (0.47) MTNR1AMTNR1BNQO2CYP2C9CYP2C19
Trifluoroacetic Acid SCHEMBL7401358 0.78 MCL1 (0.40) MCL1MTNR1AMTNR1BPPARGPPARA
SCHEMBL25946487 0.76 MTNR1A (0.41) MTNR1AMTNR1BHPNKDM4ANQO2
SCHEMBL7399530 0.76 MTNR1A (0.40) MTNR1AMTNR1BNQO2CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL7403768 0.76 CA12 (0.42) MCL1MTNR1AMTNR1BEDNRBEDNRA
SCHEMBL7316466 0.74 HTR6 (0.41) MCL1NQO2BRD9BAZ2BBAZ2A
SCHEMBL7392587 0.74 CXCR2 (0.48) MTNR1AMTNR1BNQO2PPARGCYP2C9
SCHEMBL24300007 0.74 BRD4 (0.56) KDM4ANQO2CYP2C9BRD4CREBBP
SCHEMBL7397679 0.72 MTNR1A (0.46) MTNR1AMTNR1BHPNNQO2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001034146-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2001-05-17 WO disclosed