Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14144636 | 0.71 | HSD17B10 (0.33) | NEK2 | |
| SCHEMBL12004011 | 0.69 | — | — | |
| SCHEMBL2604297 | 0.65 | NEK2 (0.32) | NEK2OPRM1 | |
| SCHEMBL20978035 | 0.64 | OPRM1 (0.31) | OPRM1 | |
| SCHEMBL9851649 | 0.62 | NEK2 (0.33) | NEK2OPRM1 | |
| SCHEMBL14829983 | 0.61 | NEK2 (0.36) | NEK2 | |
| SCHEMBL15057601 | 0.60 | GRIN1 (0.30) | — | |
| SCHEMBL17113583 | 0.60 | HSD17B10 (0.34) | NEK2 | |
| SCHEMBL1029904 | 0.59 | OPRM1 (0.41) | NEK2OPRM1 | |
| SCHEMBL14829982 | 0.58 | NEK2 (0.42) | NEK2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968288-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2016-01-20 | — | — | EP | claimed |
| WO-2014150132-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | claimed |
| EP-0711292-A1 | AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY | KOSMIN, Gerald, Emmanuel (GB) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995003303-A2 | AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY | STATE OF ISRAEL, REPRESENTED BY THE PRIME MINISTER'S OFFICE, ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 1995-02-02 | — | — | WO | disclosed |