Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614335 | 0.91 | OPRM1 (0.35) | OPRM1NEK2CRBNBACE1HTR2A | |
| SCHEMBL1373550 | 0.90 | OPRM1 (0.38) | OPRM1NEK2CRBNBACE1HTR2A | |
| SCHEMBL29749693 | 0.84 | HTR2A (0.45) | OPRM1NEK2CRBNBACE1HTR2A | |
| SCHEMBL29749786 | 0.75 | HTR2A (0.42) | OPRM1CRBNBACE1HTR2A | |
| SCHEMBL7884175 | 0.74 | HTR2A (0.67) | OPRM1BACE1HTR2A | |
| SCHEMBL29328920 | 0.73 | CRBN (0.33) | CRBN | |
| SCHEMBL2015391 | 0.71 | ALDH1A1 (0.35) | CRBN | |
| SCHEMBL3646429 | 0.71 | MEN1 (0.48) | — | |
| SCHEMBL2015392 | 0.71 | ALDH1A1 (0.35) | CRBN | |
| SCHEMBL17113601 | 0.70 | NEK2 (0.38) | OPRM1NEK2CRBNBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968591-B2 | 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments | GRUENENTHAL GMBH (DE) | 2011-06-28 | — | — | US | claimed |
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | GRUENENTHAL GMBH (DE) | 2009-05-28 | — | — | US | claimed |
| EP-2035375-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2009-03-18 | — | — | EP | claimed |
| WO-2007141039-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2007-12-13 | — | — | WO | claimed |
| WO-2025061180-A1 | NITROGEN-CONTAINING CYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 杭州多域生物技术有限公司 | 2025-03-27 | — | — | WO | disclosed |
| CN-119630673-A | PDE4B inhibitors and uses thereof | 西藏海思科制药有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-119343352-A | PDE4B inhibitors and uses thereof | 西藏海思科制药有限公司 | 2025-01-21 | — | — | CN | disclosed |
| CN-118344384-A | Compounds and uses thereof | 丹诺医药(苏州）有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-111689929-B | Sulfur fluoride (VI) compound and preparation method thereof | 斯克里普斯研究所 | 2024-05-31 | — | — | CN | disclosed |
| WO-2024032673-A1 | PDE4B INHIBITOR AND USE THEREOF | 西藏海思科制药有限公司 | 2024-02-15 | — | — | WO | disclosed |
| WO-2023241598-A1 | AROMATIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF IN PREPARATION OF ESTROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-12-21 | — | — | WO | disclosed |
| US-5998406-A | BACTERICIDES | PHARMACIA & UPJOHN COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| WO-1999024428-A1 | OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS | PHARMACIA & UPJOHN COMPANY (US) | 1999-05-20 | — | — | WO | disclosed |
| US-5668286-A | ANTIBIOTIC | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1997010223-A1 | AMINOARYL OXAZOLIDINONE N-OXIDES | PHARMACIA & UPJOHN COMPANY (US) | 1997-03-20 | — | — | WO | disclosed |
| EP-0750618-A1 | OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACIA & UPJOHN COMPANY (US) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995025106-A1 | OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACIA & UPJOHN COMPANY (US) | 1995-09-21 | — | — | WO | disclosed |
| US-4377690-A | ENOLATES, USEFUL IN PREPARING LIGHT STABILIZERS | CIBA-GEIGY CORPORATION (US) | 1983-03-22 | — | — | US | disclosed |
| US-4231921-A | COMPLEX OF A METAL WITH PIPERIDINE WITH ONE ENOLATE GROUP, POLYMERS | CIBA-GEIGY CORPORATION (US) | 1980-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | OPRL1, TPH1, OPRK1 | OPRM1 9/4885NEK2 1527/4885CRBN 4343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.