Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415020 | 0.94 | UTS2R (0.62) | UTS2RMAPK1 | |
| SCHEMBL7400619 | 0.94 | UTS2R (0.62) | UTS2RMAPK1 | |
| SCHEMBL7402928 | 0.94 | UTS2R (0.62) | UTS2RMAPK1 | |
| SCHEMBL3957208 | 0.90 | SCN9A (0.58) | MEN1KMT2ACTSKSIGMAR1 | |
| SCHEMBL7407107 | 0.90 | UTS2R (0.61) | UTS2RMAPK1 | |
| SCHEMBL2311994 | 0.89 | MEN1 (0.52) | CYP2C19SMN1; SMN2MEN1KMT2ACYP2D6 | |
| SCHEMBL7409507 | 0.88 | HRH2 (0.55) | UTS2RMAPK1CTSKSIGMAR1REN | |
| SCHEMBL7408984 | 0.88 | UTS2R (0.65) | UTS2R | |
| SCHEMBL7407663 | 0.87 | CTSK (0.67) | CTSK | |
| SCHEMBL7404900 | 0.85 | UTS2R (0.56) | UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369077-B1 | OSTEOPOROSIS, PERIODONTITIS, AND ARTHRITIS | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | disclosed |
| EP-0991753-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-07-11 | — | — | EP | disclosed |
| EP-0991753-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998050534-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |