Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 4/20 | 0.55 |
| ▸ | HRH1 | P35367 | 4/20 | 0.55 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400619 | 0.92 | UTS2R (0.62) | HRH2HRH1UTS2RMAPK1SCN9A | |
| SCHEMBL7402928 | 0.92 | UTS2R (0.62) | HRH2HRH1UTS2RMAPK1SCN9A | |
| SCHEMBL7415020 | 0.92 | UTS2R (0.62) | HRH2HRH1UTS2RMAPK1SCN9A | |
| SCHEMBL7403794 | 0.88 | UTS2R (0.55) | UTS2RMAPK1CTSKSIGMAR1REN | |
| SCHEMBL7407107 | 0.87 | UTS2R (0.61) | HRH2HRH1UTS2RMAPK1 | |
| SCHEMBL7408984 | 0.85 | UTS2R (0.65) | HRH2HRH1UTS2R | |
| SCHEMBL7724067 | 0.84 | KCNA3 (0.59) | CTSKSIGMAR1 | |
| SCHEMBL7724060 | 0.84 | KCNA3 (0.59) | CTSKSIGMAR1 | |
| SCHEMBL7404900 | 0.83 | UTS2R (0.56) | HRH2HRH1UTS2RSCN9A | |
| SCHEMBL22928915 | 0.81 | KCNA3 (0.66) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369077-B1 | OSTEOPOROSIS, PERIODONTITIS, AND ARTHRITIS | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | claimed |
| EP-0991753-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-07-11 | — | — | EP | claimed |
| EP-0991753-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-12 | — | — | EP | claimed |
| WO-1998050534-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | claimed |
| US-6369077-B1 | OSTEOPOROSIS, PERIODONTITIS, AND ARTHRITIS | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | disclosed |
| EP-0991753-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-07-11 | — | — | EP | disclosed |
| EP-0991753-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998050534-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |