Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | PDE6A | P16499 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406241 | 0.95 | L3MBTL1 (0.36) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7403583 | 0.94 | L3MBTL1 (0.36) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL7398610 | 0.87 | NPC1 (0.35) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL7405055 | 0.85 | L3MBTL1 (0.36) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL7400637 | 0.82 | SMN1; SMN2 (0.33) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL7408062 | 0.75 | XIAP (0.37) | SMN1; SMN2NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL7400071 | 0.74 | GAA (0.47) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7403586 | 0.73 | RAB9A (0.41) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL8195939 | 0.73 | GAA (0.40) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL7408066 | 0.72 | XIAP (0.55) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001090095-A1 | THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES | APOTEX INC. (CA) | 2001-11-29 | — | — | WO | disclosed |