SCHEMBL7406241

SCHEMBL7406241

CCCCOc1nsc(NCC(N)=O)n1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.36
NPC1 O15118 4/20 0.34
RAB9A P51151 4/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
MAPK1 P28482 3/20 0.34
POLB P06746 2/20 0.34
MAPK8 P45983 1/20 0.34
XIAP P98170 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
RECQL P46063 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
NFKB1 P19838 1/20 0.33
CYP2C19 P33261 1/20 0.33
STAT1 P42224 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7403583 0.99 L3MBTL1 (0.36) L3MBTL1NPC1RAB9ASMN1; SMN2MAPK1
SCHEMBL7400635 0.95 SMN1; SMN2 (0.34) L3MBTL1NPC1RAB9ASMN1; SMN2MAPK1
SCHEMBL7405055 0.86 L3MBTL1 (0.36) L3MBTL1NPC1RAB9ASMN1; SMN2MAPK1
SCHEMBL7398610 0.80 NPC1 (0.35) NPC1RAB9ASMN1; SMN2ALDH1A1MAPT
SCHEMBL7408062 0.79 XIAP (0.37) L3MBTL1NPC1RAB9ASMN1; SMN2XIAP
Hydrochloric Acid SCHEMBL7403586 0.77 RAB9A (0.41) L3MBTL1NPC1RAB9ASMN1; SMN2MAPK1
SCHEMBL8195939 0.77 GAA (0.40) L3MBTL1NPC1RAB9ASMN1; SMN2MAPK1
SCHEMBL7408066 0.76 XIAP (0.55) L3MBTL1NPC1RAB9ASMN1; SMN2MAPK1
SCHEMBL7400637 0.76 SMN1; SMN2 (0.33) L3MBTL1NPC1RAB9ASMN1; SMN2MAPK1
SCHEMBL7642932 0.75 XIAP (0.34) L3MBTL1NPC1RAB9ASMN1; SMN2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6468977-B1 COMPOUNDS USEFUL IN TREATMENT TREATMENT OF DISORDER AND/OR DISEASE CAUSED BY ACTIVITY OF ENZYMES SUCH AS HUMAN RHINOVIRUS 3C PROTEASE, TRANSGLUTAMINASE AND CATHEPSINS APOTEX INC. (CA) 2002-10-22 US disclosed
WO-2001090095-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 2001-11-29 WO disclosed
US-6162791-A Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes APOTEX INC. (CA) 2000-12-19 US disclosed
EP-1058690-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 2000-12-13 EP disclosed
WO-1999045027-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 1999-09-10 WO disclosed