Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23367841 | 0.84 | SMN1; SMN2 (0.60) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL7410067 | 0.83 | CHEK2 (0.49) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL97673 | 0.83 | EGFR (0.48) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL12311615 | 0.82 | KMT2A (0.64) | EGFRERBB2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL14183990 | 0.82 | KMT2A (0.59) | EGFRERBB2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL21652258 | 0.81 | SMN1; SMN2 (0.48) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL30962500 | 0.81 | ALDH1A1 (0.50) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL21652257 | 0.80 | NR1H4 (0.65) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL17211642 | 0.80 | ALDH1A1 (0.53) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL17213443 | 0.80 | HPGD (0.62) | ALDH1A1SMN1; SMN2MAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002006215-A1 | 3-ARYLSULFONYL-2-HYDROXY-2-METHYLPROPANOIC ACID DERIVATES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-24 | — | — | WO | disclosed |