Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8581201 | 0.91 | KMT2A (0.50) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL2127770 | 0.91 | KMT2A (0.50) | EGFRERBB2ALDH1A1POLBTDP1 | |
| SCHEMBL21652258 | 0.85 | SMN1; SMN2 (0.48) | CHEK2EGFRERBB2ALDH1A1POLB | |
| SCHEMBL18585572 | 0.85 | ATF1 (0.42) | CHEK2EGFRERBB2KMT2AMEN1 | |
| SCHEMBL23367841 | 0.84 | SMN1; SMN2 (0.60) | CHEK2EGFRERBB2ALDH1A1POLB | |
| SCHEMBL7406735 | 0.84 | HSD17B1 (0.50) | EGFRERBB2ALDH1A1TDP1KMT2A | |
| SCHEMBL7400709 | 0.83 | EGFR (0.48) | CHEK2EGFRERBB2ALDH1A1POLB | |
| SCHEMBL97673 | 0.83 | EGFR (0.48) | CHEK2EGFRERBB2ALDH1A1POLB | |
| SCHEMBL12311615 | 0.82 | KMT2A (0.64) | EGFRERBB2ALDH1A1POLBKMT2A | |
| SCHEMBL7373511 | 0.82 | KMT2A (0.64) | EGFRERBB2ALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336688-B2 | Carbocyclic compounds as ROR gamma modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2019-07-02 | — | — | US | disclosed |
| US-10336688-B2 | Carbocyclic compounds as ROR gamma modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2019-07-02 | — | — | US | disclosed |
| US-20190144375-A1 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2019-05-16 | — | — | US | disclosed |
| US-20190144375-A1 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2019-05-16 | — | — | US | disclosed |
| US-10189775-B2 | Carbocyclic compounds as ROR gamma modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2019-01-29 | — | — | US | disclosed |
| US-10189775-B2 | Carbocyclic compounds as ROR gamma modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2019-01-29 | — | — | US | disclosed |
| US-20180237382-A1 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-08-23 | — | — | US | disclosed |
| EP-3341357-A1 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017037595-A1 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-03-09 | — | — | WO | disclosed |
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| EP-0632017-B1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-06 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |
| US-5416112-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-05-16 | — | — | US | disclosed |
| EP-0632017-A1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336688-B2 | Carbocyclic compounds as ROR gamma modulators | RORB, RORC, RORA | CHEK2 3734/4885EGFR 1903/4885ERBB2 1513/4885 |
| US-10189775-B2 | Carbocyclic compounds as ROR gamma modulators | RORB, RORC, RORA | CHEK2 3734/4885EGFR 1903/4885ERBB2 1513/4885 |
| US-20190144375-A1 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | RORB, RORC, RORA | CHEK2 3838/4885EGFR 1961/4885ERBB2 1629/4885 |
| US-20180237382-A1 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | RORB, RORC, RORA | CHEK2 3838/4885EGFR 1961/4885ERBB2 1629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.