Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA3 | P34903 | 4/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399914 | 0.84 | PARP15 (0.45) | GABRA3GABRA1GABRA5GABRA2PDGFRB | |
| SCHEMBL7407573 | 0.83 | ACHE (0.46) | GABRA3GABRA1GABRA5GABRA2PDGFRB | |
| SCHEMBL7403950 | 0.83 | GABRA1 (0.48) | GABRA1GABRA2 | |
| SCHEMBL7402302 | 0.79 | GABRA3 (0.43) | GABRA3GABRA1GABRA5GABRA2PDGFRB | |
| SCHEMBL7374589 | 0.79 | GABRA3 (0.41) | GABRA3GABRA1GABRA5GABRA2PDGFRB | |
| SCHEMBL8103380 | 0.76 | GABRA3 (0.56) | GABRA3GABRA1GABRA5GABRA2 | |
| SCHEMBL7406490 | 0.75 | ACHE (0.46) | GABRA3GABRA1GABRA5GABRA2HAVCR2 | |
| SCHEMBL9001271 | 0.75 | GABRA3 (0.61) | GABRA3GABRA1GABRA5GABRA2 | |
| SCHEMBL7404911 | 0.73 | MEN1 (0.38) | GABRA3GABRA1GABRA5GABRA2METAP2 | |
| SCHEMBL7404991 | 0.71 | GABRA3 (0.43) | GABRA3GABRA1GABRA5GABRA2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013650-A | VETERINARY MEDICINE | NEUROGEN CORPORATION (US) | 2000-01-11 | — | — | US | claimed |
| WO-1994026742-A1 | CERTAIN ARYL FUSED IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-24 | — | — | WO | claimed |
| US-5212310-A | Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 1993-05-18 | — | — | US | claimed |
| US-6013650-A | VETERINARY MEDICINE | NEUROGEN CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| US-5625063-A | Certain aryl fused imidazaopyrimidines; a new class of GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 1997-04-29 | — | — | US | disclosed |
| WO-1994026742-A1 | CERTAIN ARYL FUSED IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5212310-A | Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 1993-05-18 | — | — | US | disclosed |