Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.69 |
| ▸ | CTSK | P43235 | 5/20 | 0.69 |
| ▸ | CTSL | P07711 | 4/20 | 0.69 |
| ▸ | MMP1 | P03956 | 11/20 | 0.61 |
| ▸ | MMP2 | P08253 | 11/20 | 0.61 |
| ▸ | MMP3 | P08254 | 8/20 | 0.61 |
| ▸ | CTSB | P07858 | 3/20 | 0.60 |
| ▸ | REN | P00797 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 6/20 | 0.57 |
| ▸ | MMP8 | P22894 | 5/20 | 0.57 |
| ▸ | MMP7 | P09237 | 4/20 | 0.57 |
| ▸ | FCER2 | P06734 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406653 | 0.88 | MMP1 (0.64) | CTSSCTSKCTSLMMP1MMP2 | |
| SCHEMBL7403457 | 0.87 | MMP1 (0.63) | CTSSCTSKCTSLMMP1MMP2 | |
| SCHEMBL8604283 | 0.85 | CTSS (0.53) | CTSSCTSKCTSLMMP1MMP2 | |
| SCHEMBL7431430 | 0.84 | CTSS (0.64) | CTSSCTSKCTSLMMP2CTSB | |
| SCHEMBL7314680 | 0.84 | CTSS (0.64) | CTSSCTSKCTSLMMP2CTSB | |
| SCHEMBL7406420 | 0.84 | MMP1 (0.59) | CTSSCTSKCTSLMMP1MMP2 | |
| SCHEMBL7407115 | 0.82 | MMP2 (0.57) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7887273 | 0.81 | MMP1 (0.51) | CTSSCTSKCTSLMMP1MMP2 | |
| SCHEMBL7396094 | 0.81 | MMP1 (0.55) | CTSSCTSKCTSLMMP1MMP2 | |
| SCHEMBL7367573 | 0.81 | MMP1 (0.67) | MMP1MMP2MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996035711-A1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION, AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-14 | — | — | WO | claimed |
| US-5981491-A | PEPTIDES; METALLOENZYMES; TUMOR NECROSIS FACTOR | DARWIN DISCOVERY LIMITED (GB) | 1999-11-09 | — | — | US | disclosed |
| EP-0824543-A1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION, AND THEIR THERAPEUTIC USE | Chiroscience Limited (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035711-A1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION, AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-14 | — | — | WO | disclosed |