SCHEMBL7400922

SCHEMBL7400922

O=C1C=CC(=O)c2cc[c]cc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 4/20 0.48
IDO1 P14902 3/20 0.48
PIN1 Q13526 2/20 0.48
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
AKT1 P31749 1/20 0.48
SNCA P37840 1/20 0.48
MAP2K1 Q02750 1/20 0.48
EHMT2 Q96KQ7 1/20 0.48
NSD1 Q96L73 1/20 0.48
EHMT1 Q9H9B1 1/20 0.48
S100A4 P26447 2/20 0.34
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
AURKA O14965 1/20 0.31
USP2 O75604 1/20 0.31
TRPA1 O75762 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TP53 P04637 1/20 0.31
P4HB P07237 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL157089 0.81 IDO1 (0.40) CDC25BIDO1PIN1MAOAMAOB
SCHEMBL155888 0.81 S100A4 (0.41) CDC25BIDO1PIN1MAOAMAOB
SCHEMBL7148476 0.74 MEN1 (0.43) CDC25BIDO1MAOAMAOBS100A4
SCHEMBL9799712 0.74 MEN1 (0.36) CDC25BMAOAS100A4KDM4EMEN1
SCHEMBL7838757 0.73 PTPRC (0.52) CDC25BIDO1PIN1MAOAMAOB
SCHEMBL7850715 0.73 PTPRC (0.52) CDC25BIDO1PIN1MAOAMAOB
SCHEMBL15062680 0.72
SCHEMBL15062522 0.72
SCHEMBL8491710 0.70
SCHEMBL6742148 0.70 ALDH1A1 (0.57) CDC25BIDO1MAOAMAOBSNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5254546-A Hypotensive agent E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-10-19 US claimed
EP-0524946-A4 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS 1993-03-24 EP claimed
EP-0524946-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-02-03 EP claimed
EP-0479892-A1 FUSED-RING ARYL SUBSTITUTED IMIDAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-04-15 EP claimed
WO-1991015206-A1 TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO claimed
WO-1991014367-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-03 WO claimed
WO-1991000281-A2 FUSED-RING ARYL SUBSTITUTED IMIDAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-01-10 WO claimed
EP-1130016-A1 THIOCARBAMIC ACID DERIVATIVES HOKURIKU SEIYAKU CO., LTD. (JP) 2001-09-05 EP disclosed
EP-0803252-A2 Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-10-29 EP disclosed
US-5254546-A Hypotensive agent E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-10-19 US disclosed
EP-0524946-A4 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS 1993-03-24 EP disclosed
EP-0524946-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-02-03 EP disclosed
US-5140037-A Administering cognition activators E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-08-18 US disclosed
EP-0479892-A1 FUSED-RING ARYL SUBSTITUTED IMIDAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-04-15 EP disclosed
WO-1991014367-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-03 WO disclosed
WO-1991000281-A2 FUSED-RING ARYL SUBSTITUTED IMIDAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-01-10 WO disclosed