Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 5/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741288 | 1.00 | CFD (0.36) | CFDKMT2AKDM4ECLK1RXFP1 | |
| SCHEMBL738529 | 0.93 | KMT2A (0.36) | CFDKMT2AKDM4ECLK1RXFP1 | |
| SCHEMBL740270 | 0.93 | KMT2A (0.36) | CFDKMT2AKDM4ECLK1RXFP1 | |
| SCHEMBL738530 | 0.93 | KMT2A (0.36) | CFDKMT2AKDM4ECLK1RXFP1 | |
| SCHEMBL739094 | 0.93 | CFD (0.35) | CFDKMT2AKDM4EHRH1ALDH1A1 | |
| SCHEMBL739093 | 0.93 | CFD (0.35) | CFDKMT2AKDM4EHRH1ALDH1A1 | |
| SCHEMBL740111 | 0.90 | CFD (0.34) | CFDKMT2AHRH1ALDH1A1TSHR | |
| SCHEMBL740110 | 0.90 | CFD (0.34) | CFDKMT2AHRH1ALDH1A1TSHR | |
| SCHEMBL741981 | 0.88 | CFD (0.35) | CFDKMT2AHRH1ALDH1A1TSHR | |
| SCHEMBL741982 | 0.88 | CFD (0.35) | CFDKMT2AHRH1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |