Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.52 |
| ▸ | HTR3B | O95264 | 5/20 | 0.52 |
| ▸ | HTR3A | P46098 | 5/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460828 | 0.86 | PTPN1 (0.71) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1309484 | 0.83 | RAD51 (0.58) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL13082235 | 0.83 | RAD51 (0.51) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7400768 | 0.83 | HTR3E (0.57) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1079670 | 0.83 | RAD51 (0.58) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8569855 | 0.82 | PTPN1 (0.61) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7400933 | 0.80 | RAD51 (0.61) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3789425 | 0.80 | KDM4E (0.61) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL31531840 | 0.80 | RAD51 (0.59) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27077503 | 0.77 | PTPN1 (0.43) | PTPN1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001014381-A1 | ETHER DERIVATIVES OF PYRROLO[1,2-A]QUINOXALINES, METHOD FOR PRODUCING THEM AND THEIR USE IN THERAPY | UNIVERSITE DE CAEN BASSE-NORMANDIE (FR) | 2001-03-01 | — | — | WO | disclosed |
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |