Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582780 | 0.96 | MAPT (0.39) | MAPTLMNAMAOBPTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL7401466 | 0.93 | MAPT (0.38) | MAPTLMNAMAOBPTGS1PTGS2 | |
| SCHEMBL67615 | 0.75 | MEN1 (0.46) | MAPTLMNAMAOBGRM5MAOA | |
| SCHEMBL30543406 | 0.75 | MEN1 (0.46) | MAPTLMNAMAOBGRM5MAOA | |
| SCHEMBL87071 | 0.72 | MAOB (0.37) | MAOBGRM5MAOA | |
| SCHEMBL10741838 | 0.72 | SIRT2 (0.44) | MAOBGRM5MAOA | |
| SCHEMBL12316691 | 0.72 | LMNA (0.49) | MAPTLMNAMAOBGRM5KDM4E | |
| SCHEMBL25196987 | 0.70 | ALDH1A1 (0.41) | PDE7AXDHKDM4EHTTEGFR | |
| SCHEMBL30047417 | 0.70 | ALDH1A1 (0.41) | PDE7AXDHKDM4EHTTEGFR | |
| SCHEMBL29222599 | 0.69 | MAOB (0.34) | MAOBGRM5MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012140-A1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | AstraZeneca AB (SE) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998057932-A1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |