SCHEMBL7401506

SCHEMBL7401506

COC(=O)COc1ccc2c(c1)CCC(Br)C2=O

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 4/20 0.44
CYP24A1 Q07973 4/20 0.44
CYP26A1 O43174 2/20 0.44
POLB P06746 1/20 0.43
GLA P06280 1/20 0.43
CYP27A1 Q02318 2/20 0.42
THRA P10827 1/20 0.42
THRB P10828 1/20 0.42
CYP19A1 P11511 1/20 0.41
PDK2 Q15119 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HSD17B10 Q99714 1/20 0.41
HPGD P15428 1/20 0.40
ITGB3 P05106 1/20 0.40
ITGA2B P08514 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7522985 0.86 ALOX15 (0.52) CYP24A1CYP26A1POLBCYP27A1THRA
SCHEMBL2440274 0.80 CYP24A1 (0.56) CYP24A1CYP26A1CYP27A1CYP19A1
SCHEMBL13193349 0.80 THRA (0.62) CYP24A1CYP26A1CYP27A1THRATHRB
SCHEMBL8002236 0.79 MAOB (0.52) AOC3PDK2KDM4EALDH1A1HSD17B10
SCHEMBL7528414 0.79 HSD17B10 (0.52) GLACYP19A1KDM4EALDH1A1HSD17B10
SCHEMBL7399814 0.77 MAOB (0.57) ALDH1A1HSD17B10
SCHEMBL227895 0.75 MAOB (0.61) CYP24A1ALDH1A1HPGDITGB3ITGA2B
SCHEMBL7962734 0.75 SMN1; SMN2 (0.48) CYP24A1CYP26A1CYP27A1THRATHRB
SCHEMBL7403655 0.74 CYP19A1 (0.43) AOC3CYP19A1ALDH1A1ITGB3ITGA2B
SCHEMBL14503094 0.73 GLA (0.48) GLAALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed
US-5563141-A INHIBIT CELL ADHESION FOR EXAMPLE, PLATELET AGGRE GATION ZENECA LIMITED (GB) 1996-10-08 US disclosed
EP-0690847-A1 HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1996-01-10 EP disclosed
WO-1994022835-A2 HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1994-10-13 WO disclosed