Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31588381 | 1.00 | KMT2A (0.54) | KMT2AMEN1LMNAMAPTKDM4E | |
| Bromide SCHEMBL887867 | 0.90 | MEN1 (0.47) | KMT2AMEN1LMNAMAPTKDM4E | |
| SCHEMBL27742954 | 0.88 | MEN1 (0.48) | KMT2AMEN1LMNAMAPTKDM4E | |
| Bromide SCHEMBL27458290 | 0.84 | MAPT (0.46) | KMT2AMEN1LMNAMAPTKDM4E | |
| Bromide SCHEMBL2951034 | 0.84 | MAPT (0.46) | KMT2AMEN1LMNAMAPTKDM4E | |
| SCHEMBL5940974 | 0.82 | MAPT (0.47) | KMT2AMEN1LMNAMAPTKDM4E | |
| Bromide SCHEMBL31588243 | 0.80 | TP53 (0.36) | KMT2AMEN1LMNAMAPTKDM4E | |
| Bromide SCHEMBL27893556 | 0.77 | ALDH1A1 (0.48) | KMT2AMEN1LMNAMAPTKDM4E | |
| Bromide SCHEMBL2954116 | 0.77 | ALDH1A1 (0.48) | KMT2AMEN1LMNAMAPTKDM4E | |
| SCHEMBL6289192 | 0.76 | RBP4 (0.43) | KMT2AMEN1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748464-B1 | SENSITIZERS FOR PHOTOTHERMOGRAPHIC ELEMENTS | IMATION CORP A DELAWARE CORP (US) | 1998-06-24 | — | — | EP | disclosed |
| EP-0808163-A2 | USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS | ALTEON, INC. (US) | 1997-11-26 | — | — | EP | disclosed |
| EP-0748464-A1 | SENSITIZERS FOR PHOTOTHERMOGRAPHIC ELEMENTS | Imation Corp (a Delaware Corporation) (US) | 1996-12-18 | — | — | EP | disclosed |
| WO-1996022095-A2 | USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS | ALTEON INC. (US) | 1996-07-25 | — | — | WO | disclosed |
| WO-1995023355-A1 | SENSITIZERS FOR PHOTOTHERMOGRAPHIC ELEMENTS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-08-31 | — | — | WO | disclosed |
| US-5441866-A | Benzothiazole-type cyanine dyes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-08-15 | — | — | US | disclosed |