Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | OGT | O15294 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401750 | 1.00 | KDM4E (0.38) | KDM4EOGTUSP2MAPTRECQL | |
| SCHEMBL9751642 | 0.77 | LMNA (0.44) | KDM4EOGTUSP2MAPTRECQL | |
| SCHEMBL17520158 | 0.71 | — | — | |
| SCHEMBL10995851 | 0.67 | — | — | |
| SCHEMBL10998274 | 0.65 | KDM4E (0.36) | KDM4EOGTUSP2MAPTRECQL | |
| SCHEMBL11220504 | 0.64 | KDM4E (0.31) | KDM4EOGTUSP2MAPTRECQL | |
| SCHEMBL123424 | 0.62 | — | — | |
| SCHEMBL11860477 | 0.62 | KDM4E (0.38) | KDM4EOGTUSP2MAPTRECQL | |
| SCHEMBL11310393 | 0.60 | KDM4E (0.36) | KDM4EOGTUSP2MAPTRECQL | |
| SCHEMBL11310397 | 0.60 | KDM4E (0.36) | KDM4EOGTUSP2MAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711292-A1 | AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY | KOSMIN, Gerald, Emmanuel (GB) | 1996-05-15 | — | — | EP | claimed |
| WO-1995003303-A2 | AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY | STATE OF ISRAEL, REPRESENTED BY THE PRIME MINISTER'S OFFICE, ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 1995-02-02 | — | — | WO | claimed |