Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.51 |
| ▸ | HRH1 | P35367 | 6/20 | 0.49 |
| ▸ | HRH2 | P25021 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332012 | 0.90 | HRH3 (0.48) | HRH3HRH1HRH2NPC1MAPT | |
| SCHEMBL7330409 | 0.84 | ITGB3 (0.46) | HRH3HRH1HRH2ITGB3ITGA2B | |
| SCHEMBL7395116 | 0.84 | HRH3 (0.50) | HRH3HRH1HRH2ITGB3ITGA2B | |
| SCHEMBL7392232 | 0.84 | HRH3 (0.54) | HRH3HRH1HRH2NPC1MAPT | |
| SCHEMBL7330413 | 0.83 | ITGB3 (0.47) | HRH3ITGB3ITGA2B | |
| SCHEMBL7398027 | 0.82 | MAPT (0.56) | HRH3HRH1HRH2NPC1MAPT | |
| SCHEMBL7334548 | 0.82 | ITGB3 (0.62) | HRH3HRH1HRH2NPC1MAPT | |
| SCHEMBL9275998 | 0.79 | SMN1; SMN2 (0.53) | HRH3HRH1HRH2NPC1MAPT | |
| SCHEMBL7400372 | 0.79 | SMN1; SMN2 (0.52) | HRH3HRH1HRH2NPC1MAPT | |
| SCHEMBL7401777 | 0.78 | PPARG (0.45) | HRH3NPC1SMN1; SMN2ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691959-B1 | HETEROCYCLIC DERIVATIVES AS PLATELET AGGREGATION INHIBITORS | ZENECA LTD (GB) | 1998-07-22 | — | — | EP | disclosed |
| EP-0825184-A1 | Heterocyclic derivatives as platelet aggregation inhibitors | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| EP-0690847-A1 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994022835-A2 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1994-10-13 | — | — | WO | disclosed |