Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8611482 | 0.76 | ELANE (0.55) | POLB | |
| SCHEMBL952878 | 0.71 | KMT2A (0.72) | POLBTP53KMT2AMAPTTDP1 | |
| SCHEMBL7402114 | 0.69 | TP53 (0.36) | POLBTP53KMT2AALDH1A1THRB | |
| SCHEMBL6529855 | 0.67 | KMT2A (0.56) | POLBTP53KMT2AMAPTTDP1 | |
| SCHEMBL952370 | 0.65 | KMT2A (0.62) | POLBTP53KMT2AMAPTTDP1 | |
| SCHEMBL2317433 | 0.65 | MDM2 (0.64) | POLBTP53KMT2AMAPTTDP1 | |
| SCHEMBL7268 | 0.65 | KMT2A (0.68) | POLBTP53KMT2AMAPTTDP1 | |
| SCHEMBL3299372 | 0.65 | KMT2A (0.68) | POLBTP53KMT2AMAPTTDP1 | |
| SCHEMBL28625965 | 0.64 | KMT2A (0.67) | POLBTP53KMT2AMAPTTDP1 | |
| SCHEMBL6174959 | 0.64 | TP53 (0.62) | POLBTP53KMT2AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997010243-A1 | 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (US) | 1997-03-20 | — | — | WO | disclosed |