Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 8/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411902 | 0.85 | HTR4 (0.46) | HTR4CHRM1ADRA2BADRA1AADRA1B | |
| SCHEMBL7392357 | 0.79 | HTR4 (0.38) | HTR4CHRM1ADRA2BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7417007 | 0.77 | HTR4 (0.46) | HTR4CHRM1ADRA2BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7248497 | 0.75 | HTR3A (0.53) | HTR4ADRA2BADRA1AADRA1BCHRM2 | |
| SCHEMBL7401627 | 0.71 | HTR4 (0.56) | HTR4CHRM1ADRA2BADRA1AADRA1B | |
| SCHEMBL7391971 | 0.71 | HTR4 (0.45) | HTR4CHRM1ADRA2BADRA1AADRA1B | |
| SCHEMBL4151143 | 0.71 | HTR4 (0.46) | HTR4CHRM1ADRA2BADRA1AADRA1B | |
| SCHEMBL7405651 | 0.70 | HTR4 (0.55) | HTR4CHRM1ADRA2BADRA1AADRA1B | |
| SCHEMBL7399775 | 0.70 | HTR4 (0.40) | HTR4ADRA2BADRA1AADRA1BCHRM2 | |
| SCHEMBL7360909 | 0.70 | HTR4 (0.52) | HTR4ADRA2BADRA1AADRA1BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994007859-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-14 | — | — | WO | claimed |
| EP-0662959-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007859-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-14 | — | — | WO | disclosed |