Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.46 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361069 | 0.86 | CYP1A2 (0.45) | CYP1A2ALDH1A1GRM2GRM3HSD17B10 | |
| SCHEMBL7363747 | 0.83 | GRM2 (0.44) | CYP1A2ALDH1A1GRM2GRM3HSD17B10 | |
| SCHEMBL7358486 | 0.80 | CYP1A2 (0.43) | CYP1A2ALDH1A1GRM2GRM3CYP2C19 | |
| SCHEMBL7361380 | 0.75 | FFAR4 (0.43) | CYP1A2ALDH1A1GRM2GRM3CYP2C19 | |
| SCHEMBL7398125 | 0.73 | GRM2 (0.48) | CYP1A2ALDH1A1GRM2GRM3KMT2A | |
| SCHEMBL5053068 | 0.73 | CFTR (0.42) | CYP1A2ALDH1A1GRM2GRM3CYP2D6 | |
| SCHEMBL27896730 | 0.73 | CYP1A2 (0.47) | CYP1A2ALDH1A1GRM2GRM3HSD17B10 | |
| SCHEMBL7363028 | 0.71 | SLC6A2 (0.41) | CYP1A2ALDH1A1GRM2MEN1KMT2A | |
| SCHEMBL5051258 | 0.71 | ALDH1A1 (0.41) | CYP1A2ALDH1A1 | |
| SCHEMBL7367030 | 0.71 | PTGER1 (0.42) | CYP1A2ALDH1A1MEN1KMT2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |