Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.97 |
| ▸ | PDE1A | P54750 | 5/20 | 0.97 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.97 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | PDE2A | O00408 | 4/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782824 | 0.99 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL1111560 | 0.89 | PDE5A (0.81) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL2917588 | 0.84 | PDE5A (0.74) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL4622439 | 0.83 | PDE5A (0.73) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL7089133 | 0.81 | PDE5A (0.70) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL10960178 | 0.81 | PDE5A (0.70) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL14889319 | 0.81 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL4622802 | 0.80 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL897036 | 0.79 | PDE1A (1.00) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL9927457 | 0.79 | PDE1A (0.66) | PDE5APDE1APDE1BPDE1CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022127-A1 | USE OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ANORECTAL DISORDERS | ISIS INNOVATION LIMITED (GB) | 2002-03-21 | — | — | WO | claimed |