Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.55 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | PRCP | P42785 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402728 | 1.00 | ACE (0.55) | ACERENPRCPCTRB1F2 | |
| SCHEMBL13533687 | 0.90 | PRCP (0.63) | ACERENPRCPCTRB1F2 | |
| SCHEMBL18619636 | 0.88 | MALT1 (0.55) | ACERENCTRB1F2PRSS1 | |
| SCHEMBL8434226 | 0.88 | REN (0.56) | ACERENPRCPCTRB1F2 | |
| SCHEMBL8451995 | 0.88 | REN (0.56) | ACERENPRCPCTRB1F2 | |
| SCHEMBL29872221 | 0.87 | DPP4 (0.52) | ACERENCTRB1DPP4DPP8 | |
| SCHEMBL7337615 | 0.87 | ITGB3 (0.58) | ACERENPRCPF2PRSS1 | |
| SCHEMBL8265844 | 0.85 | ACE (0.65) | ACERENCTRB1DPP4DPP8 | |
| SCHEMBL13533686 | 0.85 | ACE (0.65) | ACERENCTRB1DPP4DPP8 | |
| SCHEMBL8257846 | 0.85 | ACE (0.65) | ACERENCTRB1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |