Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR34 | Q9UPC5 | 5/20 | 0.54 |
| ▸ | MME | P08473 | 7/20 | 0.51 |
| ▸ | ACE | P12821 | 7/20 | 0.51 |
| ▸ | CPA1 | P15085 | 7/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 7/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967225 | 0.92 | ALDH1A1 (0.50) | GPR34MMEACECPA1ACE2 | |
| SCHEMBL5967322 | 0.87 | MME (0.53) | GPR34MMEACECPA1ACE2 | |
| SCHEMBL27996333 | 0.87 | MME (0.53) | GPR34MMEACECPA1ACE2 | |
| SCHEMBL7366981 | 0.84 | PSEN1 (0.44) | MMEACECPA1ACE2 | |
| SCHEMBL5966796 | 0.81 | MEN1 (0.48) | GPR34HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5967052 | 0.80 | ALDH1A1 (0.57) | — | |
| SCHEMBL27563567 | 0.80 | ALDH1A1 (0.57) | — | |
| SCHEMBL5967298 | 0.80 | PSEN1 (0.52) | — | |
| SCHEMBL5967001 | 0.79 | TSHR (0.55) | — | |
| SCHEMBL7371199 | 0.78 | PSEN1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | disclosed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |