Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.44 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 5/20 | 0.44 |
| ▸ | MME | P08473 | 5/20 | 0.44 |
| ▸ | CPA1 | P15085 | 4/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27996333 | 0.90 | MME (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967322 | 0.90 | MME (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5966867 | 0.89 | ALDH1A1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967246 | 0.84 | MMP9 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7402957 | 0.84 | GPR34 (0.54) | ACEMMECPA1ACE2 | |
| SCHEMBL7371199 | 0.83 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967298 | 0.82 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967346 | 0.82 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7359790 | 0.81 | PTPN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967166 | 0.80 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | disclosed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |