Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.53 |
| ▸ | ACE | P12821 | 4/20 | 0.53 |
| ▸ | CPA1 | P15085 | 3/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.49 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967322 | 1.00 | MME (0.53) | MMEACECPA1ACE2CTSL | |
| SCHEMBL7359790 | 0.91 | PTPN1 (0.54) | CTSLCTSBCTSSPSEN1PSEN2 | |
| SCHEMBL1460155 | 0.90 | GPR34 (0.57) | MMEACECTSLCTSBCTSS | |
| SCHEMBL7366981 | 0.90 | PSEN1 (0.44) | MMEACECPA1ACE2PSEN1 | |
| SCHEMBL27563567 | 0.90 | ALDH1A1 (0.57) | — | |
| SCHEMBL5967052 | 0.90 | ALDH1A1 (0.57) | — | |
| SCHEMBL5967233 | 0.88 | TACR1 (0.49) | ACECTSLCTSBCTSSPSEN1 | |
| SCHEMBL7402957 | 0.87 | GPR34 (0.54) | MMEACECPA1ACE2GPR34 | |
| SCHEMBL5966881 | 0.86 | KLK5 (0.48) | ACECTSLCTSBCTSSPSEN1 | |
| SCHEMBL7371199 | 0.86 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102439005-B | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators | JANSSEN PHARMACEUTICALS INC | 2015-07-22 | — | — | CN | disclosed |
| CN-102325765-B | Substituted bicyclic heterocyclic compounds as gamma-secretase modulators | JANSSEN PHARMACEUTICALS INC | 2014-12-24 | — | — | CN | disclosed |