Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29737974 | 0.92 | LMNA (0.63) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL20571599 | 0.92 | LMNA (0.63) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL762635 | 0.86 | KAT2B (0.60) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL515537 | 0.82 | KAT2B (0.81) | KAT2BLMNAMAPTPKMHTR6 | |
| SCHEMBL8246358 | 0.82 | KAT2B (0.58) | KAT2BLMNAMAPTALDH1A1PKM | |
| SCHEMBL26913572 | 0.82 | KAT2B (0.65) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8313477 | 0.82 | KAT2B (0.69) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL739095 | 0.82 | MAPT (0.64) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7745956 | 0.81 | LMNA (0.57) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL741469 | 0.81 | MAPT (0.70) | KAT2BLMNAMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |