Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629887 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AHTTKDM4E | |
| SCHEMBL2528435 | 0.81 | NCF1 (0.49) | SMN1; SMN2MEN1KMT2AHTTKDM4E | |
| SCHEMBL7400907 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2AHTTKDM4E | |
| SCHEMBL7402599 | 0.78 | ADAM17 (0.55) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7405002 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7403682 | 0.76 | ADAM17 (0.53) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL3968177 | 0.76 | ADAM17 (0.61) | ADAMTS4MMP13 | |
| SCHEMBL7404740 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4053797 | 0.75 | ADAM17 (0.60) | ADAMTS4MMP13 | |
| SCHEMBL7404237 | 0.74 | ADAM17 (0.47) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397137-A4 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1397137-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002096426-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |